This John Wayne casserole is a hearty and flavorful dish that brings together the comforting taste of ground beef, cheddar cheese, and green chiles. It's a perfect meal for those who love a bit of spice and a lot of flavor. The layers of bisquick mix, seasoned beef, and creamy toppings create a satisfying texture that is sure to please everyone at the dinner table. Whether you're feeding a crowd or just looking for a comforting family meal, this casserole is a delicious choice.
When preparing this recipe, you might find that some ingredients are not commonly stocked in every household. Bisquick mix is a versatile baking mix that is essential for creating the base layer of this casserole. If you don't have it at home, it's readily available in the baking aisle of most supermarkets. Additionally, diced green chiles add a mild heat and unique flavor to the dish, and they can usually be found in the canned goods section. Make sure to grab a packet of taco seasoning if you don't already have it in your pantry, as it adds the necessary spice to the beef.

Ingredients For John Wayne Casserole
Ground beef: Provides the hearty, meaty base for the casserole.
Taco seasoning: Adds a spicy, savory flavor to the beef.
Sour cream: Contributes a creamy texture and tangy taste to the topping.
Mayonnaise: Adds richness and creaminess to the sour cream mixture.
Cheddar cheese: Offers a sharp, cheesy flavor and melty texture.
Diced green chiles: Introduces a mild heat and distinct flavor.
Bisquick mix: Forms the base layer of the casserole, providing structure.
Water: Used to mix with the bisquick and taco seasoning.
Eggs: Help bind the bisquick mixture, giving it a light, fluffy texture.
Technique Tip for This Casserole
When preparing the ground beef, ensure it is cooked evenly by breaking it up into small pieces with a spatula as it browns. This will help the taco seasoning distribute more evenly, enhancing the flavor throughout the dish. Additionally, when mixing the bisquick layer, aim for a smooth consistency to create a sturdy base that will hold the layers together. For a more vibrant flavor, consider using freshly grated cheddar cheese instead of pre-shredded, as it melts more smoothly and adds a richer taste to the casserole.
Suggested Side Dishes
Alternative Ingredients
ground beef - Substitute with ground turkey: Ground turkey is a leaner option and absorbs flavors well, making it a suitable substitute for ground beef.
taco seasoning - Substitute with homemade taco seasoning: Combine chili powder, cumin, paprika, garlic powder, onion powder, and oregano to create a similar flavor profile.
sour cream - Substitute with Greek yogurt: Greek yogurt provides a similar tangy flavor and creamy texture while being lower in fat.
mayonnaise - Substitute with plain yogurt: Plain yogurt can mimic the creaminess of mayonnaise and is a healthier alternative.
cheddar cheese, shredded - Substitute with Monterey Jack cheese: Monterey Jack melts well and has a mild flavor that complements the dish.
diced green chiles - Substitute with jalapeños: Jalapeños offer a similar heat level and can be diced to match the texture of green chiles.
bisquick mix - Substitute with homemade baking mix: Combine flour, baking powder, salt, and shortening to create a similar base for the casserole.
water - Substitute with milk: Milk adds richness and depth to the batter, enhancing the overall flavor.
eggs - Substitute with flaxseed meal and water mixture: Mix one tablespoon of flaxseed meal with three tablespoons of water per egg to create a binding agent suitable for baking.
Alternative Recipes Similar to This Casserole
How to Store or Freeze This Casserole
Allow the casserole to cool completely at room temperature before storing. This prevents condensation from forming inside the storage container, which can make the casserole soggy.
For short-term storage, transfer the casserole to an airtight container or cover the baking dish tightly with plastic wrap or aluminum foil. Store in the refrigerator for up to 3-4 days.
For long-term storage, consider freezing the casserole. First, cut it into individual portions for easy reheating. Wrap each portion tightly in plastic wrap, then in aluminum foil to prevent freezer burn.
Place the wrapped portions in a freezer-safe bag or container, ensuring to remove as much air as possible. Label with the date and contents for easy identification. The casserole can be frozen for up to 2-3 months.
To reheat from the refrigerator, preheat your oven to 350°F (175°C). Transfer the casserole to an oven-safe dish and cover with foil. Heat for about 20-25 minutes or until warmed through.
If reheating from frozen, it's best to thaw the casserole in the refrigerator overnight. Once thawed, follow the same reheating instructions as above. If you’re in a hurry, you can reheat directly from frozen by adding an additional 10-15 minutes to the cooking time.
For a crispy top, remove the foil during the last 5 minutes of reheating. This will allow the cheese to become bubbly and golden once again, reminiscent of its freshly baked glory.
Avoid reheating in the microwave if possible, as it can make the casserole rubbery and unevenly heated. If you must use a microwave, do so in short intervals and cover with a microwave-safe lid to retain moisture.
How to Reheat Leftovers
Preheat your oven to 350°F (175°C). Place the leftover casserole in an oven-safe dish. Cover it with aluminum foil to prevent it from drying out. Heat for about 20-25 minutes or until the casserole is warmed through and the cheese is bubbly.
For a quick fix, use the microwave. Transfer a portion of the casserole to a microwave-safe plate. Cover it with a microwave-safe lid or another plate to retain moisture. Heat on medium power for 2-3 minutes, checking halfway through to ensure even heating. Stir if necessary.
If you prefer a crispy top, try reheating in a skillet. Place a slice of the casserole in a non-stick skillet over medium-low heat. Cover with a lid and let it warm for about 5-7 minutes. This method will help maintain a nice texture on the bottom layer.
For those with an air fryer, preheat it to 350°F (175°C). Place a portion of the casserole in the basket, ensuring it's not overcrowded. Heat for about 5-7 minutes. This method will give you a crispy top and a warm, gooey center.
If you have a toaster oven, it's a great alternative to a full-sized oven. Preheat to 350°F (175°C), place the casserole on a baking sheet, and cover with foil. Heat for 15-20 minutes, removing the foil for the last 5 minutes to crisp up the top.
Essential Tools for This Recipe
Skillet: Used to cook and brown the ground beef evenly.
Mixing bowl: Needed to combine the sour cream, mayonnaise, and cheese mixture.
Another mixing bowl: Used to mix the bisquick, water, and eggs until smooth.
Greased baking dish: The container where you layer the ingredients and bake the casserole.
Oven: Preheated to 350°F (175°C) for baking the casserole to a bubbly and golden brown finish.
Spatula: Handy for spreading the sour cream mixture over the beef layer.
Measuring cups: Essential for accurately measuring ingredients like sour cream, mayonnaise, and cheese.
Measuring spoons: Useful for measuring the taco seasoning and water.
Cheese grater: If you have a block of cheddar cheese, this tool will help you shred it.
Time-Saving Tips for This Casserole
Prepare ingredients in advance: Chop and measure all ingredients like cheddar cheese, sour cream, and diced green chiles before starting to cook.
Use pre-cooked beef: Save time by using pre-cooked or leftover ground beef; just reheat and add taco seasoning.
Mix dry ingredients ahead: Combine bisquick mix and other dry ingredients in advance to streamline the process.
Layer efficiently: Arrange all components like the beef mixture and sour cream mixture near your baking dish for quick assembly.
Preheat the oven early: Start preheating your oven as you begin preparation to ensure it’s ready when you are.

John Wayne Casserole Recipe
Ingredients
Main Ingredients
- 1 lb Ground Beef
- 1 packet Taco Seasoning
- 1 cup Sour Cream
- 1 cup Mayonnaise
- 1 cup Cheddar Cheese, shredded
- 1 can Diced Green Chiles
- 1 cup Bisquick Mix
- ½ cup Water
- 2 Eggs
Instructions
- Preheat oven to 350°F (175°C).
- In a skillet, cook ground beef until browned. Drain fat. Add taco seasoning and water. Simmer for 5 minutes.
- In a mixing bowl, combine sour cream, mayonnaise, and half of the shredded cheese. Set aside.
- In another bowl, mix Bisquick, water, and eggs until smooth. Pour into a greased baking dish.
- Layer cooked beef mixture over the Bisquick layer. Spread sour cream mixture over the beef. Top with remaining cheese and diced green chiles.
- Bake in preheated oven for 30 minutes or until bubbly and golden brown.
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